|
Anti-mitochondrial antibodies (AMA) are autoantibodies, consisting of immunoglobulins formed against mitochondria, primarily the mitochondria in cells of the liver. The presence of AMA in the blood or serum of a person may be indicative of the presence of, or the potential to develop, the autoimmune disease primary biliary cirrhosis (PBC; also known as primary biliary cholangitis). PBC causes scarring of liver tissue, confined primarily to the bile duct drainage system. AMA is present in about 95% of cases. PBC is seen primarily in middle-aged women, and in those afflicted with other autoimmune diseases. ==Antigens== Several of the antigens associated with anti-mitochondrial antibodies have been identified.〔Berg PA, Klein R (1992) Antimitochondrial antibodies in primary biliary cirrhosis and other disorders: definition and clinical relevance. Dig Dis 10(2):85-101〕 *M1 - cardiolipin *M2 - branched-chain alpha-keto acid dehydrogenase complex *M3 - outer mitochondrial membrane *M4 - sulfite oxidase *M5 - outer mitochondrial membrane *M6 - outer mitochondrial membrane *M7 - sarcosine dehydrogenase *M8 - outer mitochondrial membrane *M9 - glycogen phosphorylase 抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』 ■ウィキペディアで「Anti-mitochondrial antibody」の詳細全文を読む スポンサード リンク
|